New York – What does Canada Goose do to geese? That’s the question that Canadian Charmed and Descendants star Sarah Jeffery answers in a new PETA video short called “Draw My Life: Canada Goose Edition.”
In the video, the Vancouver-born actor voices the thoughts of a goose who’s born on a massive Canadian farm, raised in a filthy shed and a fenced-in pen with no protection from the extreme cold, and finally shipped off to a slaughterhouse. “Then I looked to where we were going, and I saw the blade,” she says. “This was our end. We’re going to be killed so Canada Goose can stuff our feathers into jackets for humans—even though there are countless better ways for them to keep warm that don’t require me to die.”
PETA—whose motto reads, in part, that “animals are not ours to wear”—notes that Canada Goose’s coats are also trimmed with fur from coyotes, who can suffer in traps for days before they’re shot or bludgeoned to death. A wide variety of top brands—including HoodLamb, Save the Duck, NOIZE, For All Kind, and Wuxly Movement—sell warm and stylish coats that are 100 percent vegan.
Jeffery is part of a growing list of celebrities—including Tara Strong, Maggie Q, Ireland Basinger-Baldwin, and Justin Long—who’ve joined PETA in speaking out against Canada Goose.
PETA opposes speciesism, which is the human-supremacist view that other animals are commodities for humans to breed and kill at will. For more information, please visit PETA.org.
Memorial Sloan Kettering Cancer Center (MSK) researchers presented the results of a randomized phase III trial at today’s press program for the European Society for Medical Oncology’s 2018 Congress in Munich, Germany. The results demonstrated that a combination of the immune checkpoint blocker avelumab (Bavencio®) and the tyrosine kinase inhibitor (TKI) axitinib (Inlyta®) could significantly improve progression-free survival (PFS) in people who have been previously untreated for advanced renal cell carcinoma (RCC).
In the international trial, 886 people with kidney cancer from all subgroups were administered a first-line treatment. Avelumab and axitinib were administered to 442 people via IV every two weeks, while 444 people received sunitinib (Sutent®). Researchers compared the outcomes for people with tumors that were positive for programmed cell death-ligand 1 (PD-L1+). The primary results compared were PFS in PD-L1+ patients and overall survival in PD-L1+ patients up to five years.
Robert Motzer, MD, a medical oncologist at MSK and lead study author, said, “The findings of this study suggest that combining an immune checkpoint blocker with a TKI is successful, compared to a TKI alone, and maybe a new treatment option for people with advanced renal cell carcinoma.”
Significant adverse events were experienced by 55 percent of people in the study as a whole. Adverse events leading to the discontinuation of treatment affected 4 percent of people on avelumab plus axitinib and 8 percent on sunitinib.
Median PFS in people with PD-L1+ tumors was 13.8 months in the combination arm versus 7.2 months for sunitinib, while median PFS irrespective of PD-L1 expression was 13.8 versus 8.4 months, respectively. The safety profiles were consistent with those of prior studies of each drug; no new safety signals were observed for the combination.
“The results demonstrated longer PFS and higher objective response rate for avelumab plus axitinib compared to sunitinib for treatment-naive people with RCC,” Dr. Motzer continued. “We will plan more study around overall survival. This is the first phase III trial result that compares the combination of a checkpoint inhibitor with a TKI to standard TKI treatment with sunitinib. The positive outcome is promising for this approach to become a new standard of care in first-line treatment for this cancer.”
MSK’s Pioneering Work with Immunotherapy in Kidney Cancer
Cancer immunotherapy was born at MSK over a century ago. Since then, MSK scientists have led the effort to develop immune-based treatments for cancer. MSK has been at the epicenter of discoveries in the field, and the institution’s work is bringing exciting new treatment options to people with cancer. MSK has extensive experience in using immunotherapy to treat people with melanoma, kidney cancer, lung cancer, and other cancers, as well as in handling immune-related side effects.
On November 23, 2015, the US Food and Drug Administration approved nivolumab (Opdivo®) for the treatment of RCC — research pioneered and led by Dr. Motzer. Although nivolumab was already used to treat melanoma and lung cancer, this marked the first time that the FDA approved a checkpoint inhibitor for the treatment of kidney cancer. On April 16, 2018, the FDA approved the combination of nivolumab and ipilimumab (Yervoy®) for the treatment of people with poor- and intermediate-risk advanced RCC
What This Means for People with Kidney Cancer
Despite available therapies for kidney cancer, the outlook for people with advanced RCC remains poor, with fewer than 10 percent of people surviving five years after diagnosis. It’s also a particularly aggressive disease: At the time of diagnosis, cancer has already spread to other organs in approximately 30 percent of people, and about one-third of people whose condition is confined to the kidney will have a relapse.
In 2018, it is estimated that 63,000 new cases of RCC will be diagnosed and there will be 15,000 deaths due to RCC in the United States — and numbers are expected to rise significantly in the next decade.
“Some of the most exciting progress we are making in cancer treatment is around checkpoint inhibitors,” Dr. Motzer said. “In 2018, we have seen the FDA approve the combination of nivolumab and ipilimumab for the treatment of people with poor- and intermediate-risk advanced renal cell carcinoma, and we are continuing to study and research additional treatment options for people with RCC.”
Sierra Club to Trump in California: Face the Facts on What’s Behind Destructive Wildfires
[WASHINGTON, DC] — Over the weekend, Donald Trump visited communities in California that were severely damaged by wildfire. Trump’s visit comes among reports of 80 dead, more than 1,000 missing, and thousands of homes and businesses destroyed. Trump has repeatedly denied that climate change exists, yet claimed he wants “great climate.” Scientific consensus has repeatedly stated that climate change is responsible for the increased risk of these unnaturally large and dangerous fires, with firefighters reporting serious changes in fire behavior in recent years.
In response, Sierra Club Executive Director Michael Brune ( photo ) released the following statement:
“Our thoughts are with the people of California who have and continue to suffer unimaginable loss from this unprecedented wave of wildfires. We are grateful for the firefighters, first responders and disaster relief professionals on the ground helping those who have been affected and displaced.
“Our public officials cannot stop at visits and expressions of condolences — let alone nonsensical remarks and lies — immediate action must be taken to protect our communities. As recovery efforts continue, our leaders must prioritize smart, science-based prevention efforts that acknowledge the role climate change plays in intensifying wildfires.
“We call on Donald Trump to face the facts. Take the steps that are necessary to put people, our communities, and their future first. The Sierra Club remains committed to helping the people affected by the California wildfires and to taking science-based action to protect people and communities.”
SAN FRANCISCO, Nov. 17, 2017 /PRNewswire/ — EatLove, the personalized nutrition platform and meal planning service, announced they are teaming up with AmazonFresh as one of their first recipe integration providers. Customers will now be able to combine healthy meal planning and grocery shopping in one simple click.
EatLove’s comprehensive personalization takes into account every variable and dietary consideration, including nutrition, health and lifestyle goals, food allergies as well as personal tastes and preferences. The service starts with a simple evaluation then its powerful technology creates a customized meal plan for the week complete with an optimized grocery list, daily reminders and easy to follow recipes. Customers check off the ingredients they already have at home, and the remaining grocery items can be purchased and delivered conveniently through AmazonFresh.
The platform offers a variety of over 3,000 individually tested, delicious recipes from chefs, recipe developers, dietitians and popular food bloggers with more than 900 meal plans hand crafted by registered dietitians.
According to EatLove CEO Monique Nadeau, “The collaboration with AmazonFresh is the natural next step for EatLove further simplifying weekly meal planning with online shopping and ordering, all under ten minutes.”
“EatLove has cracked the code on the comprehensive personalization required for today’s complex individual and family diets coping with any and all combinations of health and medicinal food requirements,” Nadeau said. “Our advanced algorithms can instantly analyze more than 3 million dietary factors to create the perfect meal plan and grocery list, optimized across the week’s recipes ensuring “meal kit” efficiencies at less than half the cost.”
The innovative integration of EatLove’s personalized meal planning and AmazonFresh grocery shopping will change how customers plan and shop for their weekly meals. The seamless experience further simplifies the connection between personal dietary needs and grocery shopping. Learn more at www.eatlove.is
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